Need help with...

RE: Need help with...
Author: Becky Skidmore    Posted: Mon, 23 Jun 2003 09:03:55 -0400
Hi Sheri: I have developed customized imports for both these Dialog databases. They are not perfect but seem to address the obvious problems you mention. Let me know if you are interested. Becky Becky Skidmore, BA MLS Information Specialist Canadian Coordinating Office for Health Technology Assessment (CCOHTA) 865 Carling Avenue, Suite 600 Ottawa, ON K1S 5S8 Tel: (613) 226-2553, ext. 228 Fax: (613) 226-5392 Email: /> http://www.ccohta.ca -----Original Message----- From: Hester, Sheri Sent: 19 Jun 2003 5:02 PM To: /> Subject: <RefMan> Need help with... Need help with Dialog Biosis and Embase formats I tried both of these today, on this file (attached). The Biosis format missed the journal names (even on the BIOSIS records) The Embase format got the date in the wrong place (even in the Embase records). Can you fix these formats for me? Thanks, Sheri Hester Project Manager ORISE, MS-10 P.O. Box 117 Oak Ridge, TN, 37831-0117 /> (865) 576-2011 ------_=_NextPart_000_01C336A5.FA166020 Content-Type: text/plain; name="96184 FULL DIALOG import to REF Man.txt" Content-Transfer-Encoding: quoted-printable Content-Disposition: attachment; filename="96184 FULL DIALOG import to REF Man.txt" 01174947/4 DIALOG(R)File 35:Dissertation Abs Online (c) 2003 ProQuest Info&Learning. All rts. reserv. 01174947 ORDER NO: AAD91-27711 METABOLISM AND BIOACTIVATION OF 1,2,3-TRICHLOROPROPANE (TCP) 1,2,3-Trichloropropane (TCP) causes rat hepatic DNA damage in the = form of DNA single strand breaks. This damage was dose and time dependent. = In vivo $\sp{14}$C-TCP equivalents covalently bound to hepatic protein, = RNA and DNA. Glutathione depletion with L-buthionine-(R,S)-sulfoximine increased binding to protein by 342% while it decreased binding to DNA = by 56%. The in vivo binding data suggest a dual role for glutathione in = the bioactivation of TCP. In vitro rat hepatic microsomes activated TCP to species which covalently bound to microsomal protein. Rat liver = microsomes also bioactivated TCP to the direct acting mutagen 1,3-dichloroacetone. 1,3-Dichloroacetone was identified as the major microsomal protein = binding species through conjugation with N-acetylcysteine to form 1,3-(2-propanone)-bis-S-(N-acetylcysteine) which accounted for 87% of = all TCP microsomal metabolism. These findings support a role for 1,3-dichloroacetone as a mutagenic metabolite of TCP. Carbon-13 nuclear magnetic resonance was used to identify directly = the urinary metabolite of $\sp{13}$C$\sb3$-TCP (99 atom % enrichment). = Urine was investigated directly using proton-decoupled $\sp{13}$C and two-dimensional homonuclear correlated nuclear magnetic resonance spectroscopy. Spectral shifts have been assigned to N-acetyl-S-(2-hydroxy-3-chloropropyl)cysteine, 1,3-(2-propanol)-bis-S-(N-acetylcysteine), N-acetyl-S-(2-hydroxy-2-carboxyethyl)cysteine, 2,3-dichloropropionic = acid, 2-chloroethanol, ethylene glycol and oxalic acid by comparison to = spectra of authentic standards. No unchanged TCP was detected. From the results obtained it is concluded that metabolism of TCP by cytochromes P450 and = by glutathione conjugation can result in the formation of reactive = metabolites of TCP which may be responsible for TCP genotoxicity. 10909138/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 10909138| AA- 199799530283| TI- The induction of endogenous DNA adducts in tissues of Fischer-344 = rats following gavage administration of 1,2,3-trichloropropane.| AU- La D K(a); Swenberg J A| CS- (a)Curriculum Toxicol., Univ. North Carolina, Chapel Hill, NC 27599 = USA | JN- Proceedings of the American Association for Cancer Research Annual Meeting| VO- 38| IS- 0| PG- 131| PY- 1997| CT- Eighty-eighth Annual Meeting of the American Association for Cancer Research| LO- San Diego, California, USA| DA- April 12-16, 1997| SN- 0197-016X| RT- Citation| LA- English| RN- 96-18-4: 1 2 3-TRICHLOROPROPANE| DE- <MAJOR CONCEPT> Biochemistry and Molecular Biophysics; Cell = Biology; Digestive System (Ingestion and Assimilation); Genetics; = Toxicology| DE- <BIOSYSTEMATIC> Muridae--Rodentia, Mammalia, Vertebrata, Chordata, Animalia| DE- <ORGANISMS> Muridae (Muridae)| DE- <SUPER TAXA> animals; chordates; mammals; nonhuman vertebrates; nonhuman mammals; rodents; vertebrates| DE- <CHEMICALS> 1,2,3-TRICHLOROPROPANE| DE- <MISC.> Meeting Abstract; CARCINOGEN; CARCINOGENESIS; DIGESTIVE = SYSTEM; DNA ADDUCT; ENDOGENOUS; EXOCYCLIC ADDUCT; FISCHER-344 RAT; = FORESTOMACH; GAVAGE ADMINISTRATION; INDUCTION; LIVER; MOLECULAR GENETICS; S-(1-(HYDROXYMETHYL)-2-(N7-GUANYL)ETHYL)GLUTATHIONE; = TOXICODYNAMICS; TOXICOLOGY; TUMOR BIOLOGY; 1,N-4-ETHENODEOXYCYTIDINE; 1,N-6-ETHENODEOXYADENOSINE; 1,2,3-TRICHLOROPROPANE| CC- 02506 Cytology and Cytochemistry-Animal 03506 Genetics and Cytogenetics-Animal 10060 Biochemical Studies-General 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines 10064 Biochemical Studies-Proteins, Peptides and Amino Acids 10506 Biophysics-Molecular Properties and Macromolecules 14006 Digestive System-Pathology 22501 Toxicology-General; Methods and Experimental| CC- 00520 General Biology-Symposia, Transactions and Proceedings of Conferences, Congresses, Review Annuals| BC- 86375 Muridae| 10859001/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 10859001| AA- 199799480146| TI- Chemical structure and genotoxicity in a series of = halogen-substituted propane and methane derivatives.| AU- Kharchevnikova N V; Zholdakova Z I; Zhurkov V S| CS- A.N. Sysin Res. Inst. Ecol. Hum. Ecol. Environ. Hyg., Russ. Acad. = Med. Sci., Moscow Russia| JN- Gigiena i Sanitariya| VO- 0| IS- 1| PG- 33-35| PY- 1997| SN- 0016-9900| RT- Citation| LA- Russian; Non-English| RN- 74-98-6D: PROPANE; 74-82-8D: METHANE; 96-11-7: 1 2 = 3-TRIBROMOPROPANE; 96-12-8: 1 2-DIBROMO-3-CHLOROPROPANE; 51483-40-0: 1 3-DIBROMO-2-CHLOROPROPANE; 51483-39-7: 1 = 3-DICHLORO-2-BROMOPROPANE; 33037-07-9: 1-BROMO-2 3-DICHLOROPROPANE; 96-18-4: 1 2 3-TRICHLOROPROPANE; 75-25-2: TRIBROMOMETHANE; 124-48-1: DIBROMOCHLOROMETHANE; 75-27-4: BROMODICHLOROMETHANE; 67-66-3: TRICHLOROMETHANE; 67-66-3: CHLOROFORM; 50812-37-8: GLUTATHIONE-S-TRANSFERASE| DE- <MAJOR CONCEPT> Biochemistry and Molecular Biophysics; Metabolism; Methods and Techniques; Toxicology| DE- <BIOSYSTEMATIC> Muridae--Rodentia, Mammalia, Vertebrata, Chordata, Animalia| DE- <ORGANISMS> mouse (Muridae); rat (Muridae)| DE- <SUPER TAXA> animals; chordates; mammals; nonhuman mammals; = nonhuman vertebrates; rodents; vertebrates| DE- <CHEMICALS> PROPANE; METHANE; 1,2,3-TRIBROMOPROPANE; 1,2-DIBROMO-3-CHLOROPROPANE; 1,3-DIBROMO-2-CHLOROPROPANE; 1,3-DICHLORO-2-BROMOPROPANE; 1-BROMO-2,3-DICHLOROPROPANE; 1,2,3-TRICHLOROPROPANE; TRIBROMOMETHANE; DIBROMOCHLOROMETHANE; BROMODICHLOROMETHANE; TRICHLOROMETHANE; CHLOROFORM; GLUTATHIONE-S-TRANSFERASE| DE- <MISC.> Research Article; ANIMAL MODEL; BIOCHEMISTRY AND = BIOPHYSICS; BROMODICHLOROMETHANE; CHLOROFORM; DIBROMOCHLOROMETHANE; = GENOTOXICITY; GLUTATHIONE-S-TRANSFERASE; HALOGEN-SUBSTITUTED ALIPHATIC = HYDROCARBONS; INDUSTRIAL TOXIN; MATHEMATICAL MODEL; METABOLIC ACTIVATION; NEPHROTOXICITY; PHYSICOCHEMISTRY; TOXICOLOGY; TRIBROMOMETHANE; TRICHLOROMETHANE; 1-BROMO-2,3-DICHLOROPROPANE; 1,2-DIBROMO-3-CHLOROPROPANE; 1,2,3-TRIBROMOPROPANE; 1,2,3-TRICHLOROPROPANE; 1,3-DIBROMO-2-CHLOROPROPANE; 1,3-DICHLORO-2-BROMOPROPANE| CC- 10050 Biochemical Methods-General 10060 Biochemical Studies-General 13002 Metabolism-General Metabolism; Metabolic Pathways 22501 Toxicology-General; Methods and Experimental| BC- 86375 Muridae| 10356262/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 10356262| AA- 199698811180| TI- Analysis of ras mutations in forestomach tumors from B6C3F1 mice exposed to 1,2,3-trichloropropane.| AU- Ito N(a); La D K(a); Holt S(a); Craft T R(a); Sills R C; Swenberg J = A (a)| CS- (a)Dep. Environ. Sci. Eng., Curriculum Toxicol., Univ. North = Carolina, Chapel Hill, NC 27599 USA| JN- Proceedings of the American Association for Cancer Research Annual Meeting| VO- 37| IS- 0| PG- 137| PY- 1996| CT- 87th Annual Meeting of the American Association for Cancer = Research| LO- Washington, D.C., USA| DA- April 20-24, 1996| SN- 0197-016X| RT- Citation| LA- English| RN- 96-18-4: 1 2 3-TRICHLOROPROPANE| DE- <MAJOR CONCEPT> Digestive System (Ingestion and Assimilation); = Genetics ; Metabolism; Toxicology; Tumor Biology| DE- <BIOSYSTEMATIC> Muridae--Rodentia, Mammalia, Vertebrata, Chordata, Animalia| DE- <ORGANISMS> rat (Muridae)| DE- <SUPER TAXA> animals; chordates; mammals; nonhuman mammals; = nonhuman vertebrates; rodents; vertebrates| DE- <CHEMICALS> 1,2,3-TRICHLOROPROPANE| DE- <MISC.> CARCINOGENESIS; DNA ADDUCT; H-RAS MUTATION; K-RAS MUTATION; LIPID PEROXIDATION; MEETING ABSTRACT; MEETING POSTER; S-(1-(HYDROXYMETHYL)-2-(N-7-GUANYL)ETHYL)GLUTATHIONE; SQUAMOUS CELL CARCINOMA; 1-N-6-ETHENODEOXYADENOSINE; 3-N-4-ETHENODEOXYCYTIDINE| CC- 03506 Genetics and Cytogenetics-Animal 13006 Metabolism-Lipids 14006 Digestive System-Pathology 22501 Toxicology-General; Methods and Experimental 24004 Neoplasms and Neoplastic Agents-Pathology; Clinical = Aspects; Systemic Effects 24007 Neoplasms and Neoplastic Agents-Carcinogens and = Carcinogenesis| CC- 00520 General Biology-Symposia, Transactions and Proceedings of Conferences, Congresses, Review Annuals 02506 Cytology and Cytochemistry-Animal 10060 Biochemical Studies-General 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines 10506 Biophysics-Molecular Properties and Macromolecules| BC- 86375 Muridae| 10275240/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 10275240| AA- 199698730158| TI- Dose-response relationships for carcinogens.| AU- Swenberg James A(a); La David K; Scheller Nova A; Wu Kuen-Yuh| CS- (a)Dep. Environ. Sci. Eng., Campus Box 7400, Univ. N.C., Chapel = Hill, NC 27599-7400 USA| JN- Toxicology Letters (Shannon)| VO- 82-83| IS- SPEC. ISSUE| PG- 751-756| PY- 1995| SN- 0378-4274| DT- Article| RT- Abstract| LA- English| AB- Biotransformation of chemical carcinogens involves both metabolic activation and detoxication. The molecular dose present on DNA as adducts represents a balance between these two pathways (formation) = and DNA repair. All of these are enzymatic processes subject to = saturation. When none of the pathways is saturated, linear molecular dosimetry = is expected, whereas if metabolic activation is saturated, a = supralinear response occurs. If detoxication or DNA repair is saturated, a sublinear response occurs. With chronic exposure, steady-state concentrations of DNA adducts develop and these follow the same patterns. With several alkylating agents, multiple adducts are = formed. The extent of formation is chemically defined, but different DNA = repair pathways can be involved for different adducts. By understanding = the molecular dose and biology of each adduct and comparing these to = the dose-response for tumor induction, it may be possible to identify = the most appropriate biomarkers for risk assessment. Recently, = endogenous DNA adducts identical to those induced by known human carcinogens = have been identified. These endogenously formed adducts may play an important role in human carcinogenesis.| RN- 96-18-4: 1 2 3-TRICHLOROPROPANE; 55-18-5: DIETHYLNITROSAMINE; = 62-75-9: DIMETHYLNITROSAMINE; 75-02-5: VINYL FLUORIDE; 2669-89-8: VINYL| DE- <MAJOR CONCEPT> Biochemistry and Molecular Biophysics; Genetics; Metabolism; Oncology (Human Medicine, Medical Sciences); Pollution Assessment Control and Management; Toxicology| DE- <BIOSYSTEMATIC> Hominidae--Primates, Mammalia, Vertebrata, = Chordata, Animalia| DE- <ORGANISMS> human (Hominidae)| DE- <SUPER TAXA> animals; chordates; humans; mammals; primates; = vertebrates | DE- <CHEMICALS> 1,2,3-TRICHLOROPROPANE; DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; VINYL FLUORIDE; VINYL| DE- <MISC.> DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; DNA REPAIR; VINYL CHLORIDE; VINYL FLUORIDE; 1,2,3-TRICHLOROPROPANE| CC- 03508 Genetics and Cytogenetics-Human 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines 13002 Metabolism-General Metabolism; Metabolic Pathways 13014 Metabolism-Nucleic Acids, Purines and Pyrimidines 22501 Toxicology-General; Methods and Experimental 22506 Toxicology-Environmental and Industrial Toxicology 24007 Neoplasms and Neoplastic Agents-Carcinogens and = Carcinogenesis 37015 Public Health: Environmental Health-Air, Water and Soil Pollution| CC- 10060 Biochemical Studies-General 10064 Biochemical Studies-Proteins, Peptides and Amino Acids| BC- 86215 Hominidae| 09293056/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 09293056| AA- 199497301426| TI- Characterization of DNA adducts induced by 1,2,3-trichloropropane.| AU- La D K; Yen T Y; Swenberg J| CS- Dep. Environ. Sci. and Eng., Univ. North Carolina, Chapel Hill, NC 27599 USA| JN- Proceedings of the American Association for Cancer Research Annual Meeting| VO- 35| IS- 0| PG- 108| PY- 1994| CT- 85th Annual Meeting of the American Association for Cancer = Research| LO- San Francisco, California, USA| DA- April 10-13, 1994| SN- 0197-016X| RT- Citation| LA- English| RN- 96-18-4: 1 2 3-TRICHLOROPROPANE| DE- <MAJOR CONCEPT> Biochemistry and Molecular Biophysics; Toxicology; Tumor Biology| DE- <BIOSYSTEMATIC> Muridae--Rodentia, Mammalia, Vertebrata, Chordata, Animalia| DE- <ORGANISMS> rat (Muridae)| DE- <SUPER TAXA> animals; chordates; mammals; nonhuman mammals; = nonhuman vertebrates; rodents; vertebrates| DE- <CHEMICALS> 1,2,3-TRICHLOROPROPANE| DE- <MISC.> CARCINOGENESIS; MEETING ABSTRACT| CC- 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines 10506 Biophysics-Molecular Properties and Macromolecules 22501 Toxicology-General; Methods and Experimental 24006 Neoplasms and Neoplastic Agents-Biochemistry 24007 Neoplasms and Neoplastic Agents-Carcinogens and = Carcinogenesis| CC- 00520 General Biology-Symposia, Transactions and Proceedings of Conferences, Congresses, Review Annuals 10060 Biochemical Studies-General| BC- 86375 Muridae| 07872211/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 07872211| AA- 000092131577| TI- EFFECT OF BROMINE AND CHLORINE POSITIONING IN THE INDUCTION OF = RENAL AND TESTICULAR TOXICITY BY HALOGENATED PROPANES| AU- LAG M; SODERLUND E J; OMICHINSKI J G; BRUNBORG G; HOLME J A; DAHL J = E; NELSON S D; DYBING E| CS- DEP. ENVIRON. MED., NATL. INST. PUBLIC HEALTH, GEITMYRSVEIEN 75, = N-0462 OSLO 4, NORWAY.| JN- CHEM RES TOXICOL| JN- Chemical Research in Toxicology| SO- 4 (5). 1991. 528-534.| PY- 1991| CD- CRTOE| RT- Abstract| LA- ENGLISH| AB- A series of halogenated propanes were studied for renal and = testicular necrogenic effects in the rat and correlated to their ability to = induce in vivo renal and testicular DNA damage and in vitro testicular DNA damage. 1,2-Dibromo-3-chloropropane (DBCP) and = 1,2,3-tribromopropane were most potent in causing organ damage in both kidney and testes. Extensive necrosis was evident at 85 .mu.mol/kg in kidney and at = 170 .mu.mol/kg in testis. The dibromomonochlorinated analogue 1,3-dibromo-2-chloropropane was less organ toxic than DBCP and 1,2,3-tribromopropane, but induced more organ damage than the dichloromonobrominated analogues 1-bromo-2,3-dichloropropane and 1,3-dichloro-2-bromopropane. Dihalogenated propanes were even less necrogenic. These observed differences in toxic potency between the halogenated propanes could not be explained by relative differences = in tissue concentrations. The ability of the halogenated propanes to induce DNA damage in vivo correlated well with their ability to = induce organ damage. However, DNA damage occurred at lower doses and at a shorter period of exposure than organ necrosis. This indicates that = DNA damage might be an initial event in the development of organ = necrosis by halogenated propanes in general. Further, testicular DNA damage induced by the halogenated propanes in vivo correlated well with = the DNA damage observed in isolated testicular cells in vitro, showing = that toxicity was due to in situ activation. The numbers, positions, and = the types of halogen substituents appear to be important determinants = in causing DNA damage and necrogenic effects. The toxic potential of = the halogenated propanes was in the following order: = 1,2,3-tribromopropane .gtoreq. 1,2-dibromo-3-chloropropane > 1,3-dibromo-2-chloropropane = > 1,3-dichloro-2-bromopropane .simeq. 1-bromo-2,3-dichloropropane > 1,2,3-trichloropropane .simeq. 1,2-dibromopropane .gtoreq. 1,3-dibromopropane .gtoreq. 1-bromo-3-chloropropane. The most toxic analogues contain three halogens with at least two vicinal = bromines.| DE- <RAT GENOTOXICITY QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP 1 2 = 3 TRIBROMOPROPANE 1 2 DIBROMO-3-CHLOROPROPANE 1 3 = DIBROMO-2-CHLOROPROPANE 1 3 DICHLORO-2-BROMOPROPANE 1 BROMO-2 3-DICHLOROPROPANE 1 2 3 TRICHLOROPROPANE 1 2 DIBROMOPROPANE 1 3 DIBROMOPROPANE 1 BROMO-3-CHLOROPROPANE| CC- 03506 Genetics and Cytogenetics-Animal 10060 Biochemical Studies-General 10506 Biophysics-Molecular Properties and Macromolecules 15506 Urinary System and External Secretions-Pathology 16506 Reproductive System-Pathology 17006 Endocrine System-Gonads and Placenta 22501 Toxicology-General; Methods and Experimental| CC- 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines| BC- 86375 Muridae| BC- Animals Chordates Vertebrates Nonhuman Vertebrates Mammals Nonhuman Mammals Rodents| 04875096/4 FN- DIALOG(R)File 5:Biosis Previews(R)| CZ- (c) 2003 BIOSIS. All rts. reserv.| AZ- 04875096| AA- 000030068220| TI- RESULTS OF A 90-DAY TOXICITY STUDY ON 1 2 3 TRICHLOROPROPANE AND 1 = 1 2 TRICHLOROPROPANE ADMINISTERED VIA THE DRINKING WATER| AU- VILLENEUVE D C; CHU I; SECOURS V E; COTE M G; PLAA G L; VALLI V E| CS- BUR. CHEM. HAZARDS, HEALTH PROTECT. BRANCH, OTTAWA, CAN.| JN- INTERNATIONAL SYMPOSIUM ON ORGANIC MICROPOLLUTANTS IN DRINKING = WATER AND HEALTH, AMSTERDAM, NETHERLANDS, JUNE 11-14, 1985. SCI TOTAL = ENVIRON | SO- 47 (0). 1985. 421-426.| PY- 1985| CD- STEVA| RT- Citation| LA- ENGLISH| DE- <RAT GREAT LAKES USA CANADA HEPATOTOXICITY NEPHROTOXICITY = NEUROTOXICITY THYROID TOXICITY GROWTH SEX DIFFERENCE WATER POLLUTION| CC- 07514 Ecology; Environmental Biology-Limnology 14006 Digestive System-Pathology 15506 Urinary System and External Secretions-Pathology 17018 Endocrine System-Thyroid 20506 Nervous System-Pathology 22506 Toxicology-Environmental and Industrial Toxicology 37015 Public Health: Environmental Health-Air, Water and Soil Pollution| CC- 00520 General Biology-Symposia, Transactions and Proceedings of Conferences, Congresses, Review Annuals 03510 Genetics and Cytogenetics-Sex Differences 10060 Biochemical Studies-General 12503 Pathology, General and Miscellaneous-Comparative (1970- ) 19001 Dental and Oral Biology-General; Methods 22100 Routes of Immunization, Infection and Therapy 25508 Developmental Biology-Embryology-Morphogenesis, General 52805 Soil Science-Physics and Chemistry (1970- )| BC- 86375 Muridae| BC- Animals Chordates Vertebrates Nonhuman Vertebrates Mammals Nonhuman Mammals Rodents| 07090053/4 FN- DIALOG(R)File 73:EMBASE| CZ- (c) 2003 Elsevier Science B.V. All rts. reserv.| AZ- 07090053| AA- <EMBASE> 1997371917| TI- Pollution by 1,2,3-trichloropropane| TI- <ORIGINAL> POLLUTION PAR LE 1, 2, 3-TRICHLOROPROPANE| AU- Guzik M.| CS- M. Guzik, Service de medecine du travail, rue Hospice, Montceau-les-Mines| CS- <COUNTRY> France| JN- Archives des Maladies Professionnelles et de Medecine du Travail ( ARCH. MAL. PROF. MED. TRAV. )| SO- 58/7 (636-637)| PD- 1997| PY- 1997| SN- 1250-3274| CP- France| CD- AMPTE| DT- <ITEM TYPE> Conference Paper| DT- Journal| LA- FRENCH| DE- <MAJOR DRUG TERM> polycyclic aromatic hydrocarbon --drug toxicity = --to| DE- <MINOR DRUG TERM> unclassified drug| DE- <MAJOR MEDICAL TERM> air pollution; occupational disease| DE- <MINOR MEDICAL TERM> conference paper; conjunctiva disease --epidemiology --ep; conjunctiva disease --etiology --et; digestive system disease --epidemiology --ep; digestive system disease = --etiology --et; ear nose throat disease --epidemiology --ep; ear nose throat disease --etiology --et; human; lung disease --epidemiology --ep; = lung disease --etiology --et; skin disease --etiology --et; skin disease --epidemiology --ep| ID- trichloropropylene --drug toxicity --to| SH- 017 Public Health, Social Medical and Epidemiology 035 Occupational Health and Industrial Medicine 046 Environmental Health and Pollution Control| 06050761/4 FN- DIALOG(R)File 73:EMBASE| CZ- (c) 2003 Elsevier Science B.V. All rts. reserv.| AZ- 06050761| AA- <EMBASE> 1995081072| TI- Bioassay design and MTD setting: Old methods and new approaches| AU- Swenberg J.A.| CS- Department of Environmental Science, Campus Box 7400, University of North Carolina,Chapel Hill, NC 27599| CS- <COUNTRY> United States| JN- Regulatory Toxicology and Pharmacology ( REGUL. TOXICOL. PHARMACOL. = )| SO- 21/1 (44-51)| PD- 1995| PY- 1995| SN- 0273-2300| CP- United States| CD- RTOPD| DT- <ITEM TYPE> Conference Paper| DT- Journal| LA- ENGLISH| SL- ENGLISH| AB- The proper design of carcinogenicity bioassays is critical to the interpretation and use of the data that emerge upon its completion. This paper explores some of the scientific underpinnings that need = to be considered when designing bioassays. It also discusses new approaches that can be used to improve dose setting and = interpretation of bioassay results. Critical information that determines the shape = of the dose-response curve include the molecular dose of the agent = that binds to DNA, cell proliferation, and cell death. Such data can be = used to replace default assumptions and improve the extrapolation of = risk from animal studies to humans.| TN- wy 14643| DE- <MINOR DRUG TERM> 2,3,7,8 tetrachlorodibenzo para dioxin --drug toxicity --to; dimethylnitrosamine --drug toxicity --to; ethinylestradiol --drug toxicity --to; limonene --drug toxicity = --to; mestranol --drug toxicity --to; nitrosamine --drug toxicity --to; organochlorine derivative --drug toxicity --to; phenobarbital = --drug toxicity --to; pirinixic acid --drug toxicity --to; tamoxifen = --drug toxicity --to; unclassified drug| DE- <MAJOR MEDICAL TERM> bioassay; carcinogen testing; methodology| DE- <MINOR MEDICAL TERM> cancer risk; cell death; cell proliferation; conference paper; dna binding; dose response; nonhuman; priority journal; rat; risk assessment| ID- 1,2,3 trichloropropane --drug toxicity --to| SH- 016 Cancer 035 Occupational Health and Industrial Medicine 046 Environmental Health and Pollution Control 052 Toxicology 037 Drug Literature Index| RN- 96-18-4 (1,2,3 trichloropropane); 1746-01-6 (2,3,7,8 = tetrachlorodibenzo para dioxin); 62-75-9 (dimethylnitrosamine); 57-63-6 = (ethinylestradiol) ; 138-86-3, 5989-27-5 (limonene); 72-33-3 (mestranol); 35576-91-1 ( nitrosamine); 50-06-6, 57-30-7, 8028-68-0 (phenobarbital); = 50892-23-4 ( pirinixic acid); 10540-29-1 (tamoxifen)| 03526013/4 FN- DIALOG(R)File 73:EMBASE| CZ- (c) 2003 Elsevier Science B.V. All rts. reserv.| AZ- 03526013| AA- <EMBASE> 1987042949| TI- Physiological pharmacokinetic models: Principles, applications, limitations and outlook| AU- Ritschel W.A.; Banerjee P.S.| CS- Division of Pharmaceutics and Drug Delivery System, University of Cincinnati Medical Center, Cincinnati, OH 45267| CS- <COUNTRY> United States| JN- Methods and Findings in Experimental and Clinical Pharmacology ( METHODS FIND. EXP. CLIN. PHARMACOL. )| SO- 8/10 (603-614)| PD- 1986| PY- 1986| CP- Spain| CD- MFEPD| DT- Journal| LA- ENGLISH| AB- Physiologic pharmacokinetic models are designed on the basis of = actual anatomy and physiology of the species using physiological = parameters such as organ volume, organ perfusion rate, tissue binding, = membrane permeabilities, organ metabolism rate, etc. The purpose of the = present article is to briefly review the physiological modeling and = delineate the limitations, advances made in recent years, and applicability.| DE- <MAJOR DRUG TERM> aztreonam; benzodiazepine derivative; beta lactam antibiotic; caffeine; camptothecin; chlorpheniramine; = chlorpromazine; clonazepam; cyclophosphamide; cytarabine; dichloromethane; digoxin; disopyramide; halothane; imipramine; insulin; lidocaine; lithium; metacycline; methotrexate; morphine; pentazocine; pethidine; = phenazone; phenytoin; pilocarpine; propranolol; quinidine; styrene; = sulfathiazole; tetrylammonium; theophylline; uracil arabinoside| DE- <MAJOR MEDICAL TERM> blood flow; model; pharmacokinetics| DE- <MINOR MEDICAL TERM> review; human; cardiovascular system; therapy; biological model; nonbiological model| ID- 1,2,3 trichloropropane| SH- 037 Drug Literature Index 030 Clinical and Experimental Pharmacology 027 Biophysics, Bioengineering and Medical Instrumentation| RN- 78110-38-0 (aztreonam); 30388-07-9, 58-08-2 (caffeine); 7689-03-4 ( camptothecin); 132-22-9 (chlorpheniramine); 50-53-3, 69-09-0 ( chlorpromazine); 1622-61-3 (clonazepam); 50-18-0 = (cyclophosphamide); 147-94-4, 69-74-9 (cytarabine); 75-09-2 (dichloromethane); = 20830-75-5, 57285-89-9 (digoxin); 3737-09-5 (disopyramide); 151-67-7, = 66524-48-9 ( halothane); 113-52-0, 50-49-7 (imipramine); 9004-10-8 (insulin); 137-58-6, 24847-67-4, 56934-02-2, 73-78-9 (lidocaine); 7439-93-2 ( lithium); 3963-95-9, 8026-46-8, 914-00-1 (metacycline); 15475-56-6, 59-05-2, 7413-34-5 (methotrexate); 52-26-6, 57-27-2 (morphine); 359-83-1, 64024-15-3 (pentazocine); 28097-96-3, 50-13-5, 57-42-1 ( pethidine); 60-80-0 (phenazone); 57-41-0, 630-93-3 (phenytoin); 148-72-1, 54-71-7, 92-13-7 (pilocarpine); 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6 (propranolol); 56-54-2 (quinidine); 100-42-5 (styrene); 144-74-1, 72-14-0 (sulfathiazole); 2567-83-1, 2604-85-5, 66-40-0, 77-98-5 (tetrylammonium); 58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9 (theophylline); 3083-77-0 (uracil arabinoside)| 00528672/4 FN- DIALOG(R)File 73:EMBASE| CZ- (c) 2003 Elsevier Science B.V. All rts. reserv.| AZ- 00528672| AA- <EMBASE> 1976084228| TI- Effect of 1,2,3 trichloropropane on the ploidy of rat liver cells| AU- Belyaeva N.N.; Tsulaya V.R.; Marshak T.L.; Brodskii Ya. V.| CS- Lab. Morphol., A.N. Sysin Inst. Soc. Communal Hyg., Moscow| CS- <COUNTRY> Russia| JN- Bulletin of Experimental Biology and Medicine ( BULL. EXP. BIOL. = MED. ) | SO- 78/12 (1414-1416)| PD- 1975| PY- 1975| CD- BEXBA| DT- Journal| LA- ENGLISH| AB- Cytophotometric and karyometric studies of ploidy of albino rat hepatocytes showed that after inhalation of 1,2,3 trichloropropane = in a concentration of 0.8 mg/liter, the number of mononuclear cells with = a nucleus of higher ploidy was increased and the number of binuclear cells was reduced.| DE- <MAJOR DRUG TERM> dna| DE- <MAJOR MEDICAL TERM> liver cell; polyploidy| DE- <MINOR MEDICAL TERM> theoretical study; methodology; histology; = rat; cytology| ID- propane derivative| SH- 037 Drug Literature Index 022 Human Genetics 001 Anatomy, Anthropology, Embryology and Histology| RN- 9007-49-2 (dna)| ------_=_NextPart_000_01C336A5.FA166020--

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